by chemical short-range ordering (CSRO), but there is no accurate structural tool to address CSRO characteristic, which obstacles precise composition design for HEAs. In this study, based on the cluster-plus-glue-atoms model, the composition law of Al-TMs (TMs, transition metals) HEAs with BCC and FCC structures was revealed. In BCC structure, with five elements in equi-atomic ratio, the composition formula of Al-TMs HEAs can be expressed by a cluster formula [Al-M14]Al3, and in non equi-atomic ratio can be expressed by [Al-M14]Al, where M is the average atom of the TMs. But in FCC structure, both Al-TMs HEAs with five elements in equi-atomic and non equi-atomic ratios can be expressed by a cluster formula [Al-M12]Al. To confirm the effectiveness of cluster formula for Al-TMs, two alloys were designed, [Al-Ti4V3Nb4Mo3]Mo and [Al-Ti3V3Nb4Mo4]Al. Results show that the [Al-Ti3V3Nb4Mo4]Al alloy has both higher strength and higher plastic deformation at room temperature. Besides, [Al-Ti3V3Nb4Mo4]Al alloy shows slower soften effect at 800 ºC, contributed to its higher strength. By substituting Ta for some of Mo, the strength of [Al-Ti3V3Nb4Mo3Ta]Al at room temperature and high temperature drastically decreases, suggesting that Ta element deteriorates the properties of Al-TMs alloys.